Hospital Based Birth Defects Surveillance in Kampala, Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR)

The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $1,000,000 for Year 1, subject to the availability of funds.This NOFO aims to: 1) continue a birth defects surveillance system in at least four main hospitals in Kampala, Uganda focusing on major external structural birth defects; and 2) determine if maternal use of dolutegravir, cotrimoxazole or other medications during very early pregnancy is associated with a higher risk of birth defects in newborns. Results from these activities will provide background rates of birth defects in Kampala, provide baseline estimates of maternal medication use to treat HIV in pregnancy, and ascertain any correlation between medication use and external birth defects. WHO and PEPFAR will use these findings to inform guidance regarding use of specific HIV medications during pregnancy.