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health · HHS-NIH11

Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

National Institutes of Health · RFA-HG-27-007

64 days left

Award Range

$0 – $2.0M

Total Program Funding

$15.0M

Expected Awards

5

Deadline

December 14, 2026

GRANTQUICK SUMMARYPlain-English Overview

Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed). National Institutes of Health. The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to characterize genomic variation to assess the impact of individual variants on genome function. This will be... $3,000,000 total program funding; ~5 awards expected.

Who Should Apply

Small businesses, Public And Indian Housing Authorities, County governments, Other Native American Tribal Organizations, Federally Recognized Native American Tribal Governments (+5 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

  • •See full opportunity listing for requirements

💡 GrantQuick Tip

High-value award — invest significantly in proposal quality. Consider hiring a grant writer.

Competitiveness: Very high — extremely limited awards available

What This Grant Funds

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

Public Colleges & UniversitiesNonprofits without 501(c)(3)Private Colleges & UniversitiesOther Tribal OrganizationsSmall BusinessesState Governments501(c)(3) NonprofitsFor-Profit OrganizationsPublic And Indian Housing AuthoritiesIndependent School DistrictsOther (see NOFO for details)County GovernmentsCity/Township GovernmentsFederally Recognized Tribal GovernmentsSpecial District Governments

Funding Details

Maximum Award
$2.0M
Total Program Funding
$15.0M
Expected Number of Awards
5
Cost Sharing Required?
No
Funding Instrument
cooperative_agreement

Key Dates

Posted: October 9, 2026
Application Deadline: December 14, 2026 (64 days remaining)

Agency Contact

IGVF Program Team nhgri-igvf@mail.nih.gov

nhgri-igvf@mail.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov