education · health · HHS-NIH11

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health · PAR-25-446

726 days left

Award Range

$0 – $3.0M

Deadline

August 21, 2028

GRANTQUICK SUMMARYPlain-English Overview

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional). National Institutes of Health. The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes... up to $3,000,000 per award.

Who Should Apply

City/township governments, Public And Indian Housing Authorities, Nonprofits (501c3), State governments, Federally Recognized Native American Tribal Governments (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian...
•Deadline: 2028-08-21

💡 GrantQuick Tip

Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Attachments

PDF

PAR-25-446 Full Announcement Text

PAR-25-446-Full-Announcement.html

Who Can Apply

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Eligible Applicant Types

City/Township GovernmentsPublic And Indian Housing Authorities501(c)(3) NonprofitsState GovernmentsFederally Recognized Tribal GovernmentsCounty GovernmentsFor-Profit OrganizationsPublic Colleges & UniversitiesSpecial District GovernmentsIndependent School DistrictsNonprofits without 501(c)(3)Other Tribal OrganizationsOther (see NOFO for details)Small BusinessesPrivate Colleges & Universities

Funding Details

Maximum Award: $3.0M
Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: September 10, 2025

Application Deadline: August 21, 2028 (726 days remaining)

Agency Contact

NIH Grants Information grantsinfo@nih.gov

grantsinfo@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov