health · HHS-NIH11

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

National Institutes of Health · PAR-25-442

544 days left

Deadline

February 17, 2028

GRANTQUICK SUMMARYPlain-English Overview

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed). National Institutes of Health. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or... Funding amounts not specified.

Who Should Apply

Nonprofits (501c3), City/township governments, Small businesses, Public And Indian Housing Authorities, Public universities/colleges (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Isl...
•Deadline: 2028-02-17

💡 GrantQuick Tip

Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Attachments

PDF

PAR-25-442 Full Announcement Text

PAR-25-442-Full-Announcement.html

Who Can Apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible Applicant Types

501(c)(3) NonprofitsCity/Township GovernmentsSmall BusinessesPublic And Indian Housing AuthoritiesPublic Colleges & UniversitiesFor-Profit OrganizationsOther (see NOFO for details)Special District GovernmentsIndependent School DistrictsFederally Recognized Tribal GovernmentsState GovernmentsCounty GovernmentsOther Tribal OrganizationsNonprofits without 501(c)(3)Private Colleges & Universities

Funding Details

Cost Sharing Required?: No
Funding Instrument: grant

Key Dates

Posted: June 17, 2025

Application Deadline: February 17, 2028 (544 days remaining)

Agency Contact

NIH Grants Information grantsinfo@nih.gov

grantsinfo@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov