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health · HHS-NIH11

Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

National Institutes of Health · RFA-HG-27-010

64 days left

Award Range

$0 – $800K

Total Program Funding

$5.0M

Expected Awards

5

Deadline

December 14, 2026

GRANTQUICK SUMMARYPlain-English Overview

Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed). National Institutes of Health. The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to develop, apply, and test predictive models and perform integrative analyses to determine the impact of genomic... $5,000,000 total program funding; ~5 awards expected.

Who Should Apply

Federally Recognized Native American Tribal Governments, Private universities/colleges, Nonprofits (501c3), Other Native American Tribal Organizations, For-profit organizations (+7 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

  • •Non-domestic (non-U

💡 GrantQuick Tip

High-value award — invest significantly in proposal quality. Consider hiring a grant writer.

Competitiveness: Very high — extremely limited awards available

What This Grant Funds

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to develop, apply, and test predictive models and perform integrative analyses to determine the impact of genomic variation on genome function. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers also will collaborate with other consortium components to guide and optimize IGVF experimental design, to provide analytical expertise and support for consortium-wide efforts, and to develop and execute shared analysis strategies to meet consortium goals.

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityForeign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

501(c)(3) NonprofitsIndependent School DistrictsPublic Colleges & UniversitiesSpecial District GovernmentsCity/Township GovernmentsNonprofits without 501(c)(3)Other Tribal OrganizationsFor-Profit OrganizationsSmall BusinessesFederally Recognized Tribal GovernmentsPublic And Indian Housing AuthoritiesState GovernmentsCounty GovernmentsPrivate Colleges & UniversitiesOther (see NOFO for details)

Funding Details

Maximum Award
$800K
Total Program Funding
$5.0M
Expected Number of Awards
5
Cost Sharing Required?
No
Funding Instrument
cooperative_agreement

Key Dates

Posted: October 9, 2026
Application Deadline: December 14, 2026 (64 days remaining)

Agency Contact

IGVF Program Team nhgri-igvf@mail.nih.gov

nhgri-igvf@mail.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov