health · HHS-NIH11

Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)

National Institutes of Health · RFA-MH-27-135

47 days left

Total Program Funding

$5.5M

Expected Awards

Deadline

October 11, 2026

GRANTQUICK SUMMARYPlain-English Overview

Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required). National Institutes of Health. The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance... $5,500,000 total program funding; ~5 awards expected.

Who Should Apply

State governments, City/township governments, Small businesses, Federally Recognized Native American Tribal Governments, Other eligible entities (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Refer to Section III
•Deadline: 2026-10-11

💡 GrantQuick Tip

High-value award — invest significantly in proposal quality. Consider hiring a grant writer.

Competitiveness: Very high — extremely limited awards available

What This Grant Funds

The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.

Attachments

PDF

RFA-MH-27-135-Revised-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible Applicant Types

State GovernmentsCity/Township GovernmentsSmall BusinessesFederally Recognized Tribal GovernmentsOther (see NOFO for details)Private Colleges & UniversitiesPublic And Indian Housing AuthoritiesFor-Profit OrganizationsPublic Colleges & UniversitiesIndependent School DistrictsSpecial District GovernmentsCounty GovernmentsNonprofits without 501(c)(3)501(c)(3) NonprofitsOther Tribal Organizations

Funding Details

Total Program Funding: $5.5M
Expected Number of Awards: 5
Cost Sharing Required?: No
Funding Instrument: grant

Key Dates

Posted: April 29, 2026

Application Deadline: October 11, 2026 (47 days remaining)

Agency Contact

Division of Translational Research DTRcommunications@nih.gov

DTRcommunications@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov