health · HHS-NIH11

PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional)

National Institutes of Health · RFA-RM-27-012

56 days left

Expected Awards

Deadline

October 19, 2026

GRANTQUICK SUMMARYPlain-English Overview

NIH is building the PRIMED-AI program — a consortium to develop AI models that combine medical imaging (MRI, CT, pathology) with other clinical data (genomics, labs, EHR) for precision medicine. This specific NOFO funds 8 "Data-to-Model" academic-industry partnerships where universities team with AI/tech companies to develop the algorithms. Milestone-driven: UG3 phase (2 years) → UH3 phase (3 years) if milestones met.

Who Should Apply

Research universities with medical imaging + AI expertise, partnered with industry (biotech, pharma, or AI companies). Must have access to large clinical imaging datasets and AI development capacity.

Who Should NOT Apply

Organizations without imaging + AI + clinical data infrastructure, industry partners without academic collaborators, or foreign institutions.

Key Requirements (Plain English)

•Must develop AI models integrating imaging with multimodal clinical data
•Must form academic-industrial partnership
•Must use milestone-driven UG3/UH3 structure
•Must be a US domestic institution
•8 awards expected

💡 GrantQuick Tip

This is part of a 5-NOFO constellation (D2M, M2C, Validation, Logistics, Frameworks) — you need to understand how your piece fits the larger PRIMED-AI architecture. Applications that show awareness of the full program and how their data-to-model work feeds into the validation and clinical translation NOFOs will score higher. Partner early with an industry collaborator who has production AI deployment experience.

Competitiveness: High — 8 awards for a cutting-edge NIH program. Competition is among top academic medical centers with AI labs and industry partnerships.

What This Grant Funds

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this Notice of Funding Opportunity (NOFO) is to catalyze the development and testing of Artificial Intelligence (AI)-enabled, image-centered, multimodal Clinical Decision Support (CDS) tools, developed in pursuance as Software as a Medical Device (SaMD). These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Attachments

PDF

RFA-RM-27-012-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Eligible Applicant Types

State GovernmentsIndependent School DistrictsCity/Township GovernmentsSpecial District GovernmentsPublic Colleges & UniversitiesFederally Recognized Tribal GovernmentsNonprofits without 501(c)(3)Other (see NOFO for details)Private Colleges & UniversitiesOther Tribal OrganizationsSmall BusinessesPublic And Indian Housing Authorities501(c)(3) NonprofitsCounty GovernmentsFor-Profit Organizations

Funding Details

Expected Number of Awards: 8
Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: June 30, 2026

Application Deadline: October 19, 2026 (56 days remaining)

Agency Contact

PRIMED-AI Program ODPRIMED-AI@od.nih.gov

ODPRIMED-AI@od.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov