health · HHS-NIH11

Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed)

National Institutes of Health · RFA-RM-27-011

48 days left

Award Range

$0 – $300K

Total Program Funding

$2.0M

Expected Awards

Deadline

October 9, 2026

GRANTQUICK SUMMARYPlain-English Overview

The Frameworks arm of PRIMED-AI: 5 awards (up to $300K/year) to develop reusable methodological frameworks, playbooks, and standards that the entire AI-in-medicine community can use. Think: standard approaches to AI model testing, fairness/bias auditing frameworks, multi-modal data integration standards, and responsible AI deployment guidelines for clinical imaging.

Who Should Apply

Methodologists, AI ethicists, standards developers, and research policy experts at domestic institutions. Must have expertise in developing frameworks/standards that others use — not just doing your own AI research.

Who Should NOT Apply

Teams focused on building a specific AI model (use D2M or M2C instead), institutions without standards/framework development expertise.

Key Requirements (Plain English)

•Must develop multi-use frameworks (not a single AI tool)
•Must create playbooks others can follow
•Must address fairness, reproducibility, and deployment standards
•5 awards up to $300K/year
•Must be domestic US institution

💡 GrantQuick Tip

5 awards at relatively modest funding — this is for the "standards and methods" people, not the ML engineers. If your expertise is AI ethics, bias auditing, FAIR data principles, regulatory science, or clinical implementation science, this is your niche. Frame your proposal around what FRAMEWORKS you'll produce that 50 other teams can use.

Competitiveness: Moderate — 5 awards for a supporting role. Less glamorous than building AI models, which means fewer applicants from top ML labs.

What This Grant Funds

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use. Frameworks developed through these awards would populate a "playbook", defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools. It is expected that the frameworks delineated in this playbook will directly address PRIMED-AI objectives and needs, while also remaining flexible enough to enable sufficient extensibility and interoperability for use across a broad spectrum of multimodal biomedical AI applications, both internal and external to the PRIMED-AI Program.

Attachments

PDF

RFA-RM-27-011-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible Applicant Types

Public And Indian Housing AuthoritiesPublic Colleges & UniversitiesState Governments501(c)(3) NonprofitsOther (see NOFO for details)County GovernmentsCity/Township GovernmentsIndependent School DistrictsSmall BusinessesPrivate Colleges & UniversitiesFor-Profit OrganizationsOther Tribal OrganizationsSpecial District GovernmentsFederally Recognized Tribal GovernmentsNonprofits without 501(c)(3)

Funding Details

Maximum Award: $300K
Total Program Funding: $2.0M
Expected Number of Awards: 5
Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: June 30, 2026

Application Deadline: October 9, 2026 (48 days remaining)

Agency Contact

PRIMED-AI Program ODPRIMED-AI@od.nih.gov

ODPRIMED-AI@od.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov