health · HHS-NIH11

GREGoRi Innovation Projects (U01 Clinical Trial Optional)

National Institutes of Health · RFA-HG-27-013

67 days left

Award Range

$3 – $500K

Total Program Funding

$7.5M

Expected Awards

Deadline

October 30, 2026

GRANTQUICK SUMMARYPlain-English Overview

NIH's GREGoRi Innovation Projects fund 10 awards (up to $500K each, $7.5M total) for individual research projects within the GREGoRi rare disease genomics consortium. These fund specific investigators to apply innovative genomic approaches to solve rare/undiagnosed diseases — finding the genetic causes in patients who've stumped standard clinical testing.

Who Should Apply

Rare disease genetics researchers at academic medical centers with access to undiagnosed patient cohorts and capacity for advanced genomic analysis beyond standard clinical exome/genome sequencing.

Who Should NOT Apply

Researchers without rare disease patient access, those proposing only standard clinical sequencing, common disease researchers, or groups without functional genomics capabilities.

Key Requirements (Plain English)

•Must propose innovative genomic approaches for rare/undiagnosed diseases
•Must be part of or join the GREGoRi consortium
•10 awards up to $500K each
•Clinical trials optional
•Must go beyond standard clinical genetic testing
•No cost-sharing required

💡 GrantQuick Tip

10 awards at $500K makes this accessible for rare disease geneticists. The key word is 'innovation' — don't propose standard exome sequencing that clinical labs already do. Propose long-read sequencing for structural variants, RNA-seq for splicing defects, epigenomics for imprinting disorders, or functional screens to validate variants of uncertain significance. Show you have patients who are UNSOLVED by standard approaches and explain what novel technology will crack their cases.

Competitiveness: Moderate — 10 awards for the rare disease genetics community. Researchers with unsolved patient cohorts and access to novel technologies are best positioned.

What This Grant Funds

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Attachments

PDF

RFA-HG-27-013-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Eligible Applicant Types

Private Colleges & UniversitiesSmall BusinessesNonprofits without 501(c)(3)State GovernmentsFor-Profit OrganizationsIndependent School DistrictsPublic And Indian Housing AuthoritiesCounty GovernmentsSpecial District Governments501(c)(3) NonprofitsPublic Colleges & UniversitiesCity/Township GovernmentsFederally Recognized Tribal GovernmentsOther (see NOFO for details)Other Tribal Organizations

Funding Details

Minimum Award: $3
Maximum Award: $500K
Total Program Funding: $7.5M
Expected Number of Awards: 10
Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: June 18, 2026

Application Deadline: October 30, 2026 (67 days remaining)

Agency Contact

GREGoRi Program Team nhgri-gregor@mail.nih.gov

nhgri-gregor@mail.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov