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health · HHS-NIH11

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

National Institutes of Health · PAR-26-116

207 days left

Award Range

$0$500K

Deadline

March 6, 2027

GRANTQUICK SUMMARYPlain-English Overview

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional). National Institutes of Health. The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in... up to $500,000 per award.

Who Should Apply

Nonprofits (non-501c3), State governments, Other Native American Tribal Organizations, Private universities/colleges, Nonprofits (501c3) (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

  • Refer to Section III
  • Deadline: 2027-03-06

💡 GrantQuick Tip

Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs).Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

Nonprofits without 501(c)(3)State GovernmentsOther Tribal OrganizationsPrivate Colleges & Universities501(c)(3) NonprofitsCounty GovernmentsIndependent School DistrictsCity/Township GovernmentsFor-Profit OrganizationsFederally Recognized Tribal GovernmentsOther (see NOFO for details)Special District GovernmentsPublic And Indian Housing AuthoritiesSmall BusinessesPublic Colleges & Universities

Funding Details

Maximum Award
$500K
Cost Sharing Required?
No
Funding Instrument
cooperative_agreement

Key Dates

Posted: December 8, 2025
Application Deadline: March 6, 2027 (207 days remaining)

Agency Contact

David J. Eckstein, PhD ClinicalCtrPartner@mail.nih.gov

ClinicalCtrPartner@mail.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov