health · HHS-NIH11

Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)

National Institutes of Health · PAR-26-121

639 days left

Deadline

May 26, 2028

GRANTQUICK SUMMARYPlain-English Overview

Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional). National Institutes of Health. The Maximizing Investigators' Research Award (MIRA) provides support for individual investigators for research within the scientific mission of NIGMS via a single grant to achieve the following:Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to... Funding amounts not specified.

Who Should Apply

For-profit organizations, State governments, Private universities/colleges, Public And Indian Housing Authorities, Small businesses (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Refer to Section III
•Deadline: 2028-05-26

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Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The Maximizing Investigators' Research Award (MIRA) provides support for individual investigators for research within the scientific mission of NIGMS via a single grant to achieve the following:Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to take on ambitious scientific projects and approach problems more creatively;Increase flexibility for investigators to follow important new research directions within the NIGMS mission as opportunities arise, rather than being bound to specific aims proposed in advance of the studies;More widely distribute funding among the nation's highly talented and promising investigators to increase overall scientific productivity and the chances for important breakthroughs;Reduce the time spent by researchers writing and reviewing grant applications, allowing them to spend more time conducting research;Reduce the administrative burden associated with a PD/PI managing multiple NIGMS research grants; andEnable PD(s)/PI(s) to devote more time and energy to mentoring junior scientists in a more stable research environment.This NOFO invites applications from eligible NIGMS-funded investigators and from New Investigators proposing research that is aligned with NIGMS' scientific mission. The NOFO also allows renewal applications from all current MIRA grantees (including those previously funded as Early-Stage Investigators). Current Early-Stage Investigators (ESIs) should apply through the ESI MIRA NOFO, not this NOFO.

Attachments

PDF

PAR-26-121-Full-Announcement.html

PDF

PAR-26-121-Revised-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

For-Profit OrganizationsState GovernmentsPrivate Colleges & UniversitiesPublic And Indian Housing AuthoritiesSmall BusinessesCity/Township GovernmentsNonprofits without 501(c)(3)Other (see NOFO for details)Public Colleges & UniversitiesFederally Recognized Tribal GovernmentsIndependent School DistrictsOther Tribal OrganizationsCounty GovernmentsSpecial District Governments501(c)(3) Nonprofits

Funding Details

Cost Sharing Required?: No
Funding Instrument: grant

Key Dates

Posted: December 11, 2025

Application Deadline: May 26, 2028 (639 days remaining)

Agency Contact

NIGMS EINI MIRA NIGMS_EINIMIRA@nigms.nih.gov

NIGMS_EINIMIRA@nigms.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov