health · HHS-NIH11

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

National Institutes of Health · PAR-27-058

1059 days left

Award Range

$0 – $500K

Deadline

July 5, 2029

GRANTQUICK SUMMARYPlain-English Overview

NIH/NIDCR's cooperative agreement for prospective observational or biomarker validation studies in dental/craniofacial research. Rolling deadline through 2029. Funds studies that follow patients over time or validate diagnostic/prognostic biomarkers for oral diseases — periodontitis progression, oral cancer early detection, TMJ disorders, etc.

Who Should Apply

Dental/craniofacial researchers at academic institutions with patient cohorts suitable for longitudinal observation or biomarker validation. Must have clinical dental research infrastructure.

Who Should NOT Apply

Basic science labs without clinical access, non-dental researchers, or institutions without IRB-approved patient protocols.

Key Requirements (Plain English)

•Must conduct prospective observational or biomarker validation studies
•Must focus on dental, oral, or craniofacial conditions
•Awards up to $500K
•Rolling deadline through July 2029
•Cooperative agreement (NIDCR collaboration)
•No cost-sharing required

💡 GrantQuick Tip

NIDCR cooperative agreements mean the institute is actively involved in study design — this isn't a hands-off R01. Contact NIDCR program staff to discuss your study concept before applying. They want specific biomarker validation (not discovery) or well-designed natural history studies that inform clinical decision-making. Show you have an established patient cohort ready for enrollment.

Competitiveness: Moderate — rolling deadline with no fixed awards. Quality of cohort and study design determine success.

What This Grant Funds

This Notice of Funding Opportunity (NOFO) will support, through the cooperative agreement mechanism, investigator-initiated observational studies or biomarker validation studies that require prospective collection of data/biospecimens or continued analysis of data/biospecimens.

Attachments

PDF

PAR-27-058-Full-Announcement.html

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible Applicant Types

Federally Recognized Tribal Governments501(c)(3) NonprofitsNonprofits without 501(c)(3)State GovernmentsCounty GovernmentsSmall BusinessesPublic Colleges & UniversitiesOther Tribal OrganizationsPrivate Colleges & UniversitiesIndependent School DistrictsFor-Profit OrganizationsOther (see NOFO for details)Public And Indian Housing AuthoritiesCity/Township GovernmentsSpecial District Governments

Funding Details

Maximum Award: $500K
Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: June 16, 2026

Application Deadline: July 5, 2029 (1059 days remaining)

Agency Contact

National Institute of Dental and Craniofacial Research (NIDCR) NIDCR-Program@nih.gov

NIDCR-Program@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov