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health · HHS-NIH11

NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required)

National Institutes of Health · PAR-27-065

885 days left

Deadline

March 9, 2029

GRANTQUICK SUMMARYPlain-English Overview

NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required). National Institutes of Health. The National Institute of Neurological Disorders and Stroke ( NINDS ) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on exploratory and efficacy clinical trials that address questions within the mission and... Funding amounts not specified.

Who Should Apply

Other eligible entities, Public universities/colleges, City/township governments, County governments, Special district governments (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

  • •Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U

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Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

State GovernmentsPublic And Indian Housing AuthoritiesFor-Profit OrganizationsOther Tribal OrganizationsOther (see NOFO for details)501(c)(3) NonprofitsFederally Recognized Tribal GovernmentsPrivate Colleges & UniversitiesCounty GovernmentsNonprofits without 501(c)(3)Public Colleges & UniversitiesCity/Township GovernmentsSpecial District GovernmentsSmall BusinessesIndependent School Districts

Funding Details

Cost Sharing Required?
No
Funding Instrument
cooperative_agreement

Key Dates

Posted: August 31, 2026
Application Deadline: March 9, 2029 (885 days remaining)

Agency Contact

Exploratory_Efficacy_Trials@ninds.nih.gov Exploratory_Efficacy_Trials@ninds.nih.gov

Exploratory_Efficacy_Trials@ninds.nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov