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health · HHS-NIH11

Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

National Institutes of Health · RFA-DK-27-119

175 days left

Award Range

$0$750K

Total Program Funding

$4.8M

Expected Awards

4

Deadline

February 10, 2027

GRANTQUICK SUMMARYPlain-English Overview

NIH is funding 4 Silvio O. Conte Digestive Diseases Research Core Centers (P30 grants, up to $750K each, $4.8M total) — prestigious multi-disciplinary research centers focused on digestive diseases. These provide shared core resources (imaging, biostatistics, tissue processing, animal models) that support multiple NIH-funded investigators studying GI, liver, pancreatic, and related digestive conditions.

Who Should Apply

Major research universities with 5+ NIH-funded digestive disease investigators who would benefit from shared core resources. Must demonstrate critical mass of GI research and institutional commitment.

Who Should NOT Apply

Institutions with few GI researchers, clinical practices without research programs, or universities without existing NIH-funded digestive disease research portfolios.

Key Requirements (Plain English)

  • Must support multiple NIH-funded digestive disease investigators
  • Must provide shared core resources (not individual research projects)
  • 4 awards up to $750K each
  • Must demonstrate critical mass of GI/digestive research
  • Rolling deadline through February 2027
  • No cost-sharing required

💡 GrantQuick Tip

P30 Center grants are among the most prestigious NIH mechanisms — they signal your institution is a LEADER in the field. You need 5-10 funded GI investigators who will genuinely use the cores. The strongest applications show: cores that would be too expensive for any single lab, a track record of collaboration, and institutional commitment to sustaining the center long-term. If you don't already have a digestive disease research concentration, you can't build one for this application.

Competitiveness: Very high — 4 awards for a prestigious center mechanism. Only institutions with established GI research concentrations can compete.

What This Grant Funds

This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK's mission. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of the NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Only institutions at which there is a strong ongoing base of digestive and/or liver diseases-relevant research that relates to the proposed theme of the Center are eligible. The already funded research base must have at least $3 million per year in direct costs of supported research within a proposed theme area that is of primary interest to the NIDDK. These may be a mix of Federal and privately funded research awards or research career development awards. However, at least 30 percent of the total funding contributing to the research base must be secured from the NIDDK. Moreover, enough awards within the research base must be Federal to fulfill the requirement that each Biomedical Research Core must be utilized by a minimum of two federally funded Center members. Training grants, education grants, and fellowship awards are not considered part of the research base funding. Since "Facilities and Administration" costs vary considerably between institutions, these must not be included in the calculation of the research base.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible Applicant Types

Private Colleges & UniversitiesFor-Profit OrganizationsCity/Township Governments501(c)(3) NonprofitsOther Tribal OrganizationsState GovernmentsSmall BusinessesCounty GovernmentsNonprofits without 501(c)(3)Independent School DistrictsPublic Colleges & UniversitiesSpecial District GovernmentsPublic And Indian Housing AuthoritiesFederally Recognized Tribal GovernmentsOther (see NOFO for details)

Funding Details

Maximum Award
$750K
Total Program Funding
$4.8M
Expected Number of Awards
4
Cost Sharing Required?
No
Funding Instrument
grant

Key Dates

Posted: June 16, 2026
Application Deadline: February 10, 2027 (175 days remaining)

Agency Contact

NIDDK Division of Digestive Diseases and Nutrition NIDDK_DDN@nih.gov

NIDDK_DDN@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov