health · HHS-NIH11

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies

National Institutes of Health · PAR-26-057

Closed

Deadline

TBD

GRANTQUICK SUMMARYPlain-English Overview

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies. National Institutes of Health. The National Institute of Neurological Disorders and Stroke, National Institute of Aging, the NIH Helping to End Addiction Long Term (HEAL) initiative , and other participating ICs seek to support applications to conduct... Funding amounts not specified.

Who Should Apply

Independent school districts, Nonprofits (501c3), Small businesses, For-profit organizations, City/township governments (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U

💡 GrantQuick Tip

Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The National Institute of Neurological Disorders and Stroke, National Institute of Aging, the NIH Helping to End Addiction Long Term (HEAL) initiative, and other participating ICs seek to support applications to conduct pharmacodynamic, pharmacokinetic, and efficacy studies to demonstrate that the proposed therapeutic agent(s) have sufficient biological activity to warrant further development as therapeutics for disorders or diseases supported by participating ICs or for non-opioid analgesic therapeutics with little or no addiction liability as a part of the NIH HEAL initiative. Therapeutic agents include small molecules or biologics. Efficacy testing can be conducted in validated in vivo models and/or validated New Approach Methodologies (NAMs) as appropriate.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Who Can Apply

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Eligible Applicant Types

Independent School Districts501(c)(3) NonprofitsSmall BusinessesFor-Profit OrganizationsCity/Township GovernmentsSpecial District GovernmentsCounty GovernmentsState GovernmentsOther (see NOFO for details)Federally Recognized Tribal GovernmentsOther Tribal OrganizationsPrivate Colleges & UniversitiesPublic And Indian Housing AuthoritiesNonprofits without 501(c)(3)Public Colleges & Universities

Funding Details

Cost Sharing Required?: No
Funding Instrument: grant

Key Dates

Posted: February 25, 2026

Application Deadline: TBD (0 days remaining)

Agency Contact

NINDS_IGNITE@nih.gov Please contact via email

NINDS_IGNITE@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov