health · HHS-NIH11

Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed)

National Institutes of Health · PAR-26-132

Closed

Deadline

TBD

GRANTQUICK SUMMARYPlain-English Overview

Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed). National Institutes of Health. The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on Alzheimer's disease (AD) and AD-related dementias (ADRD) drug target validation and early-stage drug discovery against novel targets. This NOFO will utilize the... Funding amounts not specified.

Who Should Apply

Other eligible entities, Small businesses, Public universities/colleges, Private universities/colleges, Nonprofits (non-501c3) (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

•Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U

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Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on Alzheimer's disease (AD) and AD-related dementias (ADRD) drug target validation and early-stage drug discovery against novel targets. This NOFO will utilize the U01 activity code. The NOFO will support rigorous preclinical AD/ADRD drug target validation and early-stage drug discovery of small molecules, biologic, and emerging therapeutic modalities. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into AD/ADRD and drug discovery are encouraged to begin to consider applying for this new NOFO.

Who Can Apply

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Eligible Applicant Types

Other (see NOFO for details)Small BusinessesPublic Colleges & UniversitiesPrivate Colleges & UniversitiesNonprofits without 501(c)(3)Special District GovernmentsFor-Profit OrganizationsFederally Recognized Tribal GovernmentsCounty Governments501(c)(3) NonprofitsOther Tribal OrganizationsCity/Township GovernmentsPublic And Indian Housing AuthoritiesState GovernmentsIndependent School Districts

Funding Details

Cost Sharing Required?: No
Funding Instrument: cooperative_agreement

Key Dates

Posted: March 4, 2026

Application Deadline: TBD (0 days remaining)

Agency Contact

NIA Scientific Contact Please contact via e-mail.

NIA-NOFO-Scientific@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov

View on Grants.gov