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health · HHS-NIH11

Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

National Institutes of Health · PAR-27-053

617 days left

Deadline

June 16, 2028

GRANTQUICK SUMMARYPlain-English Overview

Exploratory Clinical Neuroscience Research on Substance Use Disorders. National Institutes of Health. This Notice of Funding Opportunity (NOFO) uses a R61/R33 Phased Innovation Award mechanism to support clinical research applications that are exploratory and developmental in nature and focus on understanding the neurobiological mechanisms underlying SUD, including fundamental brain function... ~6 awards expected.

Who Should Apply

State governments, Public And Indian Housing Authorities, Other Native American Tribal Organizations, Small businesses, City/township governments (+10 more)

Who Should NOT Apply

Organizations not matching the eligible applicant types listed above

Key Requirements (Plain English)

  • •Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U

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Focus your proposal on clear outcomes, alignment with agency priorities, and demonstrate organizational capacity.

Competitiveness: High — limited number of awards

What This Grant Funds

This notice of funding opportunity (NOFO) uses a R61/R33 Phased Innovation Award activity code to support clinical research applications that are exploratory and developmental in nature and focus on understanding the neurobiological mechanisms underlying substance use disorders (SUD), including fundamental circuitry and behavior relevant to substance use. For projects not requiring a phased research approach, applicants are encouraged to apply under a different funding activity code (e.g., PA-25-305 "Research Project Grant (Parent R01 Clinical Trial Required)" or its subsequent reissue).

Attachments

Who Can Apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Eligible Applicant Types

For-Profit OrganizationsSmall BusinessesPrivate Colleges & UniversitiesPublic And Indian Housing AuthoritiesSpecial District GovernmentsCity/Township GovernmentsOther (see NOFO for details)Public Colleges & UniversitiesNonprofits without 501(c)(3)Other Tribal OrganizationsState GovernmentsIndependent School DistrictsFederally Recognized Tribal Governments501(c)(3) NonprofitsCounty Governments

Funding Details

Cost Sharing Required?
No
Funding Instrument
grant

Key Dates

Posted: August 31, 2026
Application Deadline: June 16, 2028 (617 days remaining)

Agency Contact

Division of Neuroscience and Behavior (DNB) NIDA_DNB_BCNB_r61@nih.gov

NIDA_DNB_BCNB_r61@nih.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov