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health · HHS-CDC-NCHHSTP

Controlling and Preventing STIs in US Health Departments (CAP-STIs)

Centers for Disease Control - NCHHSTP · CDC-RFA-PS-27-0008

Closed

Total Program Funding

$500.0M

Expected Awards

59

Deadline

TBD

GRANTQUICK SUMMARYPlain-English Overview

Controlling and Preventing STIs in US Health Departments (CAP-STIs). Centers for Disease Control - NCHHSTP. CDC is funding programs that track, prevent, and control sexually transmitted infections (STI) in state, district, territorial, and city or county health departments. The purpose of this NOFO is to track, prevent, and control three common STIs: syphilis, gonorrhea, and chlamydia. The... $500,000,000 total program funding; ~59 awards expected.

Who Should Apply

Unrestricted (any eligible entity), Other eligible entities, City/township governments, County governments, State governments (+1 more)

Who Should NOT Apply

Few restrictions — most eligible entities can apply

Key Requirements (Plain English)

  • All fifty (50) states, the District of Columbia, the US Virgin Islands and Puerto Rico are eligible to apply

💡 GrantQuick Tip

High-value award — invest significantly in proposal quality. Consider hiring a grant writer.

Competitiveness: Moderate to high — federal grants are always competitive

What This Grant Funds

CDC is funding programs that track, prevent, and control sexually transmitted infections (STI) in state, district, territorial, and city or county health departments.

The purpose of this NOFO is to track, prevent, and control three common STIs: syphilis, gonorrhea, and chlamydia.

The NOFO supports the goals of the Sexually Transmitted Infections National Strategic Plan 2021-2025:

  • Prevent new STIs.
  • Improve the health of people by reducing adverse outcomes of STIs.
  • Implement STI prevention technology and innovations more quickly.
  • Reduce the impact of STIs in areas or populations disproportionately impacted by STIs.
  • Achieve integrated, coordinated efforts that address the STI epidemic.

Local surveillance data will determine the priority populations for this NOFO. Each program should focus on populations that are disproportionately impacted by STI transmission. 

To be successful with this NOFO, you will need to collaborate with partners to address interconnected comorbidities and sexual health.

Who Can Apply

All fifty (50) states, the District of Columbia, the US Virgin Islands and Puerto Rico are eligible to apply. To ensure implementation of STI control and prevention nationwide, CDC intends to fund all fifty states, the District of Columbia, the US Virgin Islands and Puerto Rico, non-competitively, according to a funding formula based on the respective jurisdiction"s population & morbidity of three reportable STIs (chlamydia, gonorrhea and primary & secondary syphilis).Section 318(c) of the Public Health Services Act, 42 USC 247c(c), provides that the Secretary of HHS may provide funding to "States and, in consultation with the State health authority, to political subdivisions of States..." to conduct STI prevention & control projects. This language allows CDC to fund cities in addition to their respective states. Under the previous STI prevention & control funding opportunity PS19-1901 (& prior to that, PS14-1402), CDC funded the following cities based upon population, STI morbidity & organizational capacity: New York City, Philadelphia, Baltimore, Chicago, Los Angeles & San Francisco.To maximize the efficiency of program delivery, CDC may again fund a limited number of cities under this award. Funding for cities will be awarded competitively, based on the same criteria shown above for the state formula: population, STI morbidity, as well as organizational capacity. Directly funded cities must have a demonstrated capacity to report chlamydia, gonorrhea and syphilis surveillance data to CDC; an agreement with their parent state to apply separately for NOFO funding & to coordinate/collaborate appropriately following any funding; & data showing that the surrounding metropolitan statistical area (MSA) reported 2024 data showing:> or = to 500 cases of syphilis aged 15-44 reported in 2024 > or = 7500 cases of gonorrhea aged 15-44 reported in 2024 > or = to 15,000 cases of chlamydia aged 15-44 reported in 2024 > or = to 4 million residents estimated in 2024 Cities that apply for funding must submit their 2024 surveillance summary demonstrating the number of required cases & residents, a joint statement of collaboration/coordination with their respective state, or a letter indicating the city has notified the state of its application for funding of this award. In the event that cities do not compete successfully for the funding, all funds will be provided to the state, which will be responsible for distributing funds to its constituent cities as appropriate.

Eligible Applicant Types

City/Township GovernmentsOther (see NOFO for details)State GovernmentsCounty GovernmentsSpecial District Governments

Funding Details

Total Program Funding
$500.0M
Expected Number of Awards
59
Cost Sharing Required?
No
Funding Instrument
cooperative_agreement

Key Dates

Posted: May 11, 2026
Application Deadline: TBD (0 days remaining)

Agency Contact

Mary McFarland 404.639.8309

xzm3@cdc.gov

Ready to apply?

View the full NOFO and submit your application on Grants.gov