Substance Abuse Grants
248 active federal grants matching "substance abuse". Updated daily.
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)
HHS-NIH11 · RFA-DA-28-012
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)
HHS-NIH11 · RFA-DA-28-011
National Digital Newspaper Program
NEH · 20270113-PJ
Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)
HHS-NIH11 · RFA-AI-27-018
Silicon Carbide Cladding Lead Test Rod Development-Phase 1
DOE-ID · DE-FOA-0003577
Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)
HHS-NIH11 · RFA-AI-28-031
Cooperative Agreement for Affiliated Partner with the Southern Appalachian Cooperative Ecosystem Studies Unit (CESU)
DOI-USGS1 · G27AS00165
Solid Waste Management Grant Program
USDA-RUS · SWMFY27
Technical Assistance and Training Grant Program
USDA-RUS · TAT-FY27
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II
USDA-NIFA · USDA-NIFA-SBIR-012221
Small Business Transportation Technical Assistance Center (Region 3)
DOT-OSDBU · OST-OSDBU-2027-SBTTAC-REGION3-FY2027-1
Small Business Transportation Technical Assistance Center (Region 1)
DOT-OSDBU · OST-OSDBU-2027-SBTTAC-REGION1-FY2027-1
BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
HHS-NIH11 · RFA-NS-28-010
NIJ FY 2026 Invited to Apply - Novel Psychoactive Substance Discovery, Education, and Reporting Institute
USDOJ-OJP-NIJ · O-NIJ-2026-172784
FY 2027 Continuation of Solicitation for the Office of Science Financial Assistance Program
PAMS-SC · DE-FOA-0003665
Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)
HHS-NIH11 · RFA-MH-27-125
The Science, Mathematics and Research for Transformation (SMART) Scholarship for Service Program Cooperative Agreement
DOD-AMC · W911NF-27-R-A001
WATER RESOURCES RESEARCH ACT PROGRAM NATIONAL COMPETITIVE GRANTS FY2026 (104g General)
DOI-USGS1 · G27AS00164
Region 4 Small Business Transportation Technical Assistance Center (SBTTAC)
DOT-OSDBU · OST-OSDBU-2027-SBTTAC-REGION-4-FY2027-1
F26AS00023 FY2026 Prescott Marine Mammal Rescue and Response Grant Program
DOI-FWS · F26AS00023
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
HHS-NIH11 · PAR-27-045
NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed)
HHS-NIH11 · PAR-28-072
Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed)
HHS-NIH11 · PAR-28-057
BJA FY 2026 Tribal Justice Training and Technical Assistance Program
USDOJ-OJP-BJA · O-BJA-2026-172727
Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)
HHS-NIH11 · PAR-28-056
About Substance Abuse Grants
The federal government funds substance abuse programs through competitive grants posted on Grants.gov. Eligible applicants typically include 501(c)(3) nonprofits, state/local governments, tribal organizations, and educational institutions. Applications usually require a project narrative, budget justification, and evidence of organizational capacity. New opportunities post year-round with 30-60 day application windows.