Opioid Prevention Grants

The federal government funds opioid programs through competitive grants posted on Grants.gov. Eligible applicants typically include 501(c)(3) nonprofits, state/local governments, tribal organizations, and educational institutions. Applications usually require a project narrative, budget justification, and evidence of organizational capacity. New opportunities post year-round with 30-60 day application windows.

Opioid Prevention Grants

Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed)

Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)

NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)

Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)

Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)

Limited Competition: Stimulating Access to Research in Residency Transition Scholar (StARRTS) (K38 Clinical Trial Not Allowed)

Neural Ensembles &amp; Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)

OJJDP FY 2026 Opioid Affected Youth Initiative

OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use

Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)

HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)

Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)

Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)

BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)

Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed)

Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed)

BJA FY 2026 Tribal Justice Training and Technical Assistance Program

Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)

About Opioid Prevention Grants

Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)